Changes to BNF maximum dose for haloperidol
The British National Formulary (BNF) has reduced its maximum daily intramuscular (IM) dose for haloperidol from 20mg to 12mg. The maximum daily dose for the oral route remains at 20mg.
This is the second time this year that the BNF has adjusted the dose for this antipsychotic: in May 2014 the maximum daily oral and IM doses were amended from 30mg to 20mg and from 18mg to 20mg, respectively, to reflect changes in the Haldol product literature. The latest change is in response to clinical feedback from mental health practitioners that the accepted bioavailability from the oral route is about 60% of that from the IM route.
The BNF doses differ from the product literature provided by some manufacturers, but the Medicines and Healthcare products Regulatory Agency is working on harmonising the literature for all haloperidol products, including generics.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20065648
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