Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Antibacterial agents

New bactericidal enzyme solution could help the fight against MRSA infection

New endolytic enzyme called Staphefekt found to kill meticillin-resistant Staphylococcus aureus (pictured)

Source: Wikimedia Commons

Scientists have developed an endolytic enzyme called Staphefekt, which has been found to kill meticillin-resistant Staphylococcus aureus (pictured)

An enzyme that kills meticillin-resistant Staphylococcus aureus (MRSA) has been developed by Dutch biotech company Micreos.

Staphefekt is not a conventional antibiotic but an endolytic enzyme that, like those formed by bacteriophages, breaks down bacterial cell walls.

Bacteriophages are viruses that infect the particular host bacteria on which they depend in order to proliferate. After infection and replication, they produce endolysins, which target bacterial cell walls from within, causing the cell to burst and die. Staphefekt has a similar mode of action except that it attacks the bacterial cell wall from the outside.

Because its mechanism of action is unrelated to that of antibiotics, organisms that are resistant to conventional antibiotics are susceptible to Staphefekt.

Results presented at a EuroSciCon meeting in London on 5 November 2014 suggest that Staphefekt is unlikely to result in resistance because it targets an area of the bacterium wall that is less susceptible to mutation. Also, since it acts specifically against S aureus, beneficial bacteria are not affected.

The product is the first endolytic enzyme available for human use and must only be applied to intact skin. The product is available in single use containers of 30ml solution at a cost of €69.50.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067116

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.