Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

sections

Infectious diseases

World's first vaccine against the Dengue virus approved in Mexico

The first vaccine in the world to prevent the dengue virus has been approved for use in Mexico, the country’s drugs regulator has announced. In the image, close-up of the Aedes aegypti mosquito, responsible for dengue fever

Source: James Gathany / CDC

Dengue is spread by infected mosquitoes — most commonly the Aedes aegypti mosquito (pictured)

The first vaccine to prevent dengue fever has been approved for use in Mexico, the country’s drugs regulator has announced.

The decision by the Federal Commission for the Protection against Sanitary Risk (COFEPRIS) was based on the results of more than 25 clinical trials conducted by vaccine manufacturer Sanofi Pasteur in 15 countries – including Mexico – which involved more than 40,000 volunteers.

Dengvaxia is a chimeric tetravalent vaccine for prevention of disease caused by all four dengue virus serotypes (l, ll, lll and lV) and is made from attenuated dengue. The product is authorised for use in populations where dengue is endemic.

COFEPRIS says the vaccine has an average efficacy of 60.5% for preventing infection and 93.2% efficacy for preventing severe dengue infection in patients aged 9–45 years.

The regulator estimates that the vaccine could help prevent 8,000 hospital admissions and 104 deaths every year from the virus in Mexico, saving 1,100 million pesos in healthcare costs. In 2014, Mexico recorded 32,100 cases of dengue fever.

José Luis Arredondo García, associate director of clinical research at the National Institute of Pediatrics in Mexico, says: “The first vaccine approved to prevent dengue fever is a major innovation and a public health breakthrough. Dengvaxia will be a critical addition to the integrated dengue prevention and control efforts.”

Manufacturer Sanofi Pasteur, based in Lyon, France, has spent more than 20 years developing a vaccine. The company claims it has the potential to reduce cases of dengue fever by 50% within five years in populations where the disease is endemic.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20200301

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • The first vaccine to prevent dengue fever has been approved for use in Mexico, the country’s drugs regulator has announced. In the image, close-up of the Aedes aegypti mosquito, responsible for transmitting dengue fever

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.