Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Inflammatory bowel disease

Antibiotics in late pregnancy linked to inflammatory bowel disease

Researchers found that exposure to the antibiotic cefoperazone resulted in gut microbial imbalances in the mother that were transmitted to their offspring.

Xray showing inflammatory bowel disease

Source: Sovereign, ISM / Science Photo Library

Peripartum antibiotics have been suggested as risk factors for human inflammatory bowel disease (IBD), but a clear causal link between the two has never been proven.

In a study, published in Cell Reports (11 July 2017), researchers examined the temporal impact of the commonly used, broad-spectrum antibiotic cefoperazone on maternal and offspring gut microbiota when administered to IL-10-deficient mice during the peripartum period[1].

It was found that exposure to the antibiotic resulted in gut microbial imbalances in the mother, which were then transmitted to their offspring and persisted up to eight weeks after the antibiotic was stopped. These changes were associated with a skewed immune profile in the offspring which left them at a higher risk for the development of spontaneous and chemically induced colitis later in life.

These findings support a potential role of broad-spectrum antibiotics as a risk factor for IBD when used during the peripartum period in genetically susceptible hosts, the researchers conclude.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203334

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Pathology and Therapeutics for Pharmacists

    Pathology and Therapeutics for Pharmacists

    An practical, integrated approach to the pathophysiological and pharmacotherapeutic principles underlying the treatment of disease.

    £54.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • International Research in Healthcare

    International Research in Healthcare

    Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.

    £38.00Buy now
  • Biological Therapeutics

    Biological Therapeutics

    An introduction to the treatment of disease using biological medicines derived from living plant and animal tissues.

    £33.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.