Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Drug development

Antidiabetic agent could smother pancreatic cancer stem cells

Metformin, commonly used for diabetes, was found to shut down metabolism in pancreatic cancer stem cells, which can spread cancer around the body.

Pancreatic ductal adenocarcinoma (micrograph pictured) is a cancer with rising incidence and very poor outcomes.Metformin, used for diabetes, was found to shut down metabolism in pancreatic cancer stem cells, which can spread cancer around the body

Source: KGH / Wikimedia Commons

New treatments are needed for patients diagnosed with pancreatic ductal adenocarcinoma (micrograph pictured) and researchers have found the diabetes drug metformin shows promise in the laboratory  

Pancreatic ductal adenocarcinoma (PDAC) is a cancer with rising incidence and very poor outcomes, and there is a lack of effective treatments.

Pancreatic cancers are made up of different populations of cells, including pancreatic cancer stem cells. These can renew themselves, and spread tumours around the body. Researchers at Queen Mary’s University, London, found that metformin, a commonly used diabetes drug, can kill cancer stem cells by stopping oxidative metabolism in mitochondria, effectively cutting off their energy supply. The cells can develop resistance, but this can be prevented or reversed with inhibitors of MYC — a transcription factor involved in metabolism.

This approach could lead to therapies that specifically kill pancreatic cancer stem cells, with the aim of reducing recurrence after treatment, conclude the authors in Cell Metabolism (online, 10 September 2015)[1].

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20069408

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmacy Registration Assessment Questions 2

    Pharmacy Registration Assessment Questions 2

    Pharmacy Registration Assessment Questions 2 features more than 400 entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own. All questions are in line with current GPhC guidance, enabling you to prepare for the pharmaceutical pre-registration exam with confidence.

    £35.00Buy now
  • Pharmacy Registration Assessment Questions 3

    Pharmacy Registration Assessment Questions 3

    Pharmacy Registration Assessment Questions 3 is the third volume in a series that follows on from the previous, highly popular Pharmacy Registration Assessment Questions 2. It features more than 400 entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own.

    £35.00Buy now
  • Pharmacy Registration Assessment Questions Package

    Pharmacy Registration Assessment Questions Package

    Pharmacy Registration Assessment Questions is a revision series featuring closed book and calculation questions. It can be used in conjunction with previous volumes or on its own to help you prepare for the GPHC exams.

    £80.00Buy now
  • Palliative Care Formulary (PCF6)

    Palliative Care Formulary (PCF6)

    Palliative Care Formulary is a comprehensive combination of independent information about drugs used in palliative care.

    £55.00Buy now
  • Martindale: The Complete Drug Reference

    Martindale: The Complete Drug Reference

    Martindale: The Complete Drug Reference provides reliable, unbiased and evaluated information on drugs and medicines used throughout the world.

    £570.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Pancreatic ductal adenocarcinoma (micrograph pictured) is a cancer with rising incidence and very poor outcomes.Metformin, used for diabetes, was found to shut down metabolism in pancreatic cancer stem cells, which can spread cancer around the body

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.