Cancer: Body out of sync
The body clock of mammals — or circadian rhythm — is synchronised with the cell-division cycle, but little is known about how the two work together.
Now a team of researchers from The Rockefeller University in New York have imaged single proliferating fibroblasts in mice and found that the cell division cycle is set to the tissue-level clock in a 1:1 fashion1.
When they used a drug to disrupt this synchronized behaviour, cell division began to outpace the circadian clock, leading to rapid cell proliferation. This, the researchers say, could help explain why shift-workers are more susceptible to cancer and might better inform chemotherapy.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20065562
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