Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Randomised controlled trials

Chondroitin sulfate alleviates symptoms in knee osteoarthritis

Study shows positive effects of medicine in managing pain and improving mobility in patients with osteoarthritis.

Recently, the use of analgesics to treat symptoms of knee osteoarthritis (OA) has been challenged on the grounds of low efficacy and side effects.

A randomised controlled trial, published in the Annals of Rheumatic Diseases[1] (online, 22 May 2017), assessed the use of pharmaceutical-grade chondroitin sulfate (CS) in the management of symptomatic knee OA. In the study, 199 patients received pharmaceutical-grade CS, 199 received the non-steroidal anti-inflammatory drug celecoxib, and 205 received placebo.

The researchers discovered that both CS and celecoxib reduced pain and improved function more than placebo at six months but found no difference between the effects of the two drugs.

CS has potential importance for management of knee OA, but the effects obtained with pharmaceutical-grade CS cannot be extrapolated to over-the-counter preparations, which differ substantially in terms of their pharmacokinetics and pharmacodynamics, the researchers conclude.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202938

Readers' comments (1)

  • It is not easy to discover exactly what the supposed differences are between the "pharmaceutical-grade" chondroitin sulfate used in this study and the allegedly inferior "nutraceutical-grade" materials used in earlier studies. Neither this study nor any of the earlier cited studies provides any meaningful comparative analytical data on the chemical compositions of the chondroitin sulfate products used. The reader is simply asked to accept that "Chemical analysis of purity and active ingredient content of a randomly selected sample of the active study treatment capsules was conducted by an independent laboratory (Chemika, Australia) immediately after delivery of each batch of study treatment capsules to the dispatching centre. At each analysis, purity and stated active ingredient content was confirmed." I would characterise this as a serious failure in both the reporting of these studies and in the peer review of this and the earlier manuscripts!

    Unsuitable or offensive? Report this comment

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Sport and Exercise Medicine for Pharmacists

    Sport and Exercise Medicine for Pharmacists

    All the information you need to provide patients with evidence-based advice on sports and exercise related health matters.

    £27.00Buy now
  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • Popular Medicines

    Popular Medicines

    An illustrated history of some of the most popular branded medicines. Includes colourful historical adverts and details of the medicine's formula and intended purpose.

    £22.00Buy now
  • Complementary and Alternative Medicine

    Complementary and Alternative Medicine

    A practical reference source on alternative and complementary therapies. Enables healthcare professionals to give knowledge-based advice.

    £43.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Xray showing knee osteoarthritis

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.