Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Pregnancy

COX-2 inhibitors might prevent pre-eclampsia

Cyclooxygenase (COX)-2 inhibitor celecoxib reversed early signs of pre-eclampsia in pregnant mice.

Doctor performs an ultrasound in early pregnancy

Source: Shutterstock.com

Abnormal embryo implantation in early pregnancy can lead to the dangerous condition pre-eclampsia

Pre-eclampsia is characterised by hypertension and proteinuria in late pregnancy and can be life threatening. It is associated with events in early pregnancy resulting in abnormal embryo implantation, but the mechanisms are not well understood. 

US researchers studied a mouse model of pre-eclampsia and found upregulated levels of uterine cyclooxygenase (COX)-2 and interleukin-15 in early pregnancy. This was associated with decreased levels of decidual natural killer cells, known to be essential for normal embryo implantation. 

A single dose of the COX-2 inhibitor celecoxib at the time of implantation reversed these effects, and improved fetal growth and late gestational hypertension in mothers. 

Reporting in JCI Insight (online, 17 March 2016)[1], the researchers conclude that COX-2 inhibition in early pregnancy should be explored as a way to prevent pre-eclampsia.

Citation: The Pharmaceutical Journal DOI: 10.1211/CP.2016.20200909

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

RPS publications

Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.

Visit rpharms.com

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Doctor performs an ultrasound in early pregnancy

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.