Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Anticoagulants

Dagibatran carries reduced fracture risk compared with warfarin

Among patients with nonvalvular atrial fibrillation, study data show the use of dabigatran rather than warfarin was associated with a lower risk of osteoporotic fracture.

Xray of a femur with a fracture from osteoporosis

Source: Medical Photo NHS Lothian / Science Photo Library

Researchers found the risk of osteoporotic fracture was significantly lower among dabigatran users than warfarin users.

Warfarin has been associated with increased risk of osteoporotic fractures but it has been suggested that dabigatran, which has a different mode of action, might not carry the same risk.

To explore, researchers studied data from a Hong Kong hospital taken from patients with nonvalvular atrial fibrillation, including 3,268 new dabigatran users which were matched to 4,884 new warfarin users.

During a mean follow-up of 501 days, the risk of osteoporotic fracture was significantly lower among dabigatran users than warfarin users (0.7 vs 1.1 per 100 person-years). However, the association with lower risk was only statistically significant for patients with a history of fractures and/or falls (1.6 vs 3.6 per 100 person-years) but not for those without (0.6 vs 0.7 per 100 person years).

Reporting in JAMA[1] (online, 21 March 2017), the researchers suggest that patients could be screened for osteoporotic risk to inform anticoagulant choice, but the findings warrant further investigation.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202567

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 1 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £138.50Buy now
  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 2 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £262.50Buy now
  • Patient Care in Community Practice

    Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £22.00Buy now
  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00Buy now
  • Strategic Medicines Management

    Strategic Medicines Management

    A practical guide to influencing the availability of medicines, and policies of their use. Focuses on the strategic elements of medicines management.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Xray of a femur with a fracture from osteoporosis

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.