Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Diabetes

Degludec liraglutide combination improves glucose control in type 2 diabetes

Combination of insulin and GLP-1 receptor agonists could help control glucose in type 2 diabetes, researchers suggest.

Model of glycated haemoglobin

Source: Scott Camazine / Science Photo Library

Glycated haemoglobin levels were lower in patients given a combination of insulin degludec and liraglutide compared with patients whose insulin dose was increased

Most type 2 diabetes patients treated with basal insulin don’t achieve adequate glucose control. But intensifying the insulin dose can increase the risk of hypoglycaemia and weight gain. 

Researchers studied 557 patients with uncontrolled type 2 diabetes despite treatment with insulin glargine and metformin. They were randomly assigned to have their insulin dose titrated up or to receive treatment with insulin degludec and GLP-1 receptor agonist liraglutide in a single formulation. 

Over 26 weeks, the degludec and liraglutide combination treatment significantly reduced glycated haemoglobin (HbA1c) levels compared with continued insulin titration. Patients also experienced fewer hypoglycaemic episodes and greater weight loss, the researchers report in JAMA (online, 1 March 2016)[1]

The researchers conclude that combinations of insulin and GLP-1 receptor agonists could overcome barriers to glucose control in type 2 diabetes, but longer-term studies are needed.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2016.20200838

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Model of glycated haemoglobin

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.