Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Disappointing results for fish oil in atrial fibrillation trial


Source: Maevian 31/Dreamstime

Taking fish oil for up to 16 months did not reduce markers risk of atrial fibrillation

Recent trials of fish oil for prevention of atrial fibrillation (AF) recurrence have provided mixed results. In the quest for a definitive answer, researchers led by Anil Nigam, from the University of Montreal, Canada, performed AFFORD, a double-blind, randomised, placebo-controlled trial in 337 patients with symptomatic paroxysmal or persistent AF.

According to the research published in Journal of the American College of Cardiology (2014;64[14]:1441-1448)[1], high-dose fish oil (4g/day) did not reduce the primary endpoint, symptomatic or asymptomatic AF recurrence, versus placebo when taken for up to 16 months (median 271 days). AF recurrence rates were 64.1% with fish-oil supplements and 63.2% with placebo. Markers of inflammation and oxidative stress were not reduced by fish oil, which the researchers say may explain its lack of efficacy. 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066948

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

RPS publications

Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.