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Supplements

Disappointing results for fish oil in atrial fibrillation trial

fish-oil-capsules

Source: Maevian 31/Dreamstime

Taking fish oil for up to 16 months did not reduce markers risk of atrial fibrillation

Recent trials of fish oil for prevention of atrial fibrillation (AF) recurrence have provided mixed results. In the quest for a definitive answer, researchers led by Anil Nigam, from the University of Montreal, Canada, performed AFFORD, a double-blind, randomised, placebo-controlled trial in 337 patients with symptomatic paroxysmal or persistent AF.

According to the research published in Journal of the American College of Cardiology (2014;64[14]:1441-1448)[1], high-dose fish oil (4g/day) did not reduce the primary endpoint, symptomatic or asymptomatic AF recurrence, versus placebo when taken for up to 16 months (median 271 days). AF recurrence rates were 64.1% with fish-oil supplements and 63.2% with placebo. Markers of inflammation and oxidative stress were not reduced by fish oil, which the researchers say may explain its lack of efficacy. 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066948

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