Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Effective depression treatment could improve opioid cessation

Research published in the British Journal of Psychiatry has shown that opioid cessation may be more successful if concomitant depression is also effectively treated

Chronic prescription opioid use and depression in patients with non-cancer pain are mutually reinforcing, but research has not previously looked at whether treating depression improves the likelihood of chronic users achieving opioid cessation.

To explore, researchers studied data on 2,821 adults with non-cancer, non-HIV pain, with a new episode of depression following more than 90 days of opioid use, and who received at least one prescription for antidepressant medication[1].

At 24 weeks, those who adhered to their antidepressant medication (>80% of days covered) were more likely to stop continuous opioid use, which was defined as a gap of at least 182 days from the end-date of the last opioid prescription (57.2 vs 45.0/1,000 person-years; P=0.007). Antidepressant adherence equated to a 24% greater odds of opioid cessation.

Reporting in the British Journal of Psychiatry (1 February 2018), the researchers said the results indicated that opioid cessation may be more successful if concomitant depression is treated to remission.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20204611

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Close up of oxycodone pills

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.