Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Lipid-regulating drugs

Effectiveness of statins similar for men and women

A recent study shows that statin therapy reduced lipid levels by a similar extent in both men and women. In the image, the chemical structure of atorvastatin, a drug from the statin drug class


Statin therapy (image shows molecular structure of atorvastatin) reduces lipid levels by a similar extent in both men and women

The relative efficacy of statins in women versus men is unclear, particularly in primary prevention. To resolve this question, the Cholesterol Treatment Trialists’ Collaboration undertook a meta-analysis of data from 27 statin trials involving 174,149 people, 27% of whom were women.

As reported in The Lancet (online, 9 January 2015)[1], statin therapy reduced lipid levels by a similar extent in both men and women. The incremental reduction in major vascular events with statin therapy was also similar in men and women, including in women at low baseline risk. Likewise, the proportional reductions in major coronary events, coronary revascularisation and stroke did not differ significantly by gender.

The authors conclude: “In men and women at an equivalent risk of cardiovascular disease, statin therapy is of similar effectiveness for the prevention of major vascular events.” 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20067600

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.