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Engineered protein primes antibody response to HIV

An experimental HIV-1 vaccine has demonstrated immunogenicity in mice, according to recent studies. In the image, a scientist observes test subjects (white mice) in a laboratory

Source: Ragne Kabanova

Researchers administered eOD-GT8 60mer to mice, inducing the production of broadly neutralising antibody precursors

An experimental HIV-1 vaccine has demonstrated immunogenicity in mice, according to studies published concurrently in Cell[1] and Science[2] (online, 18 June 2015), with the results described as “pretty spectacular” by one of the researchers.

The new vaccine is an engineered protein, or immunogen, that binds to a precursor of broadly neutralising antibodies (bnAbs). Achieving such binding has been a major hurdle in the development of an HIV vaccine and the new protein, called eOD-GT8 60mer, represents an important advance towards an effective vaccine.

When administered to mice, eOD-GT8 60mer induced the production of antibodies with characteristics of a certain class of bnAb precursors. “The vaccine appears to work well in our model to ‘prime’ the antibody response,” says David Nemazee, one of the senior study authors.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068849

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