Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Respiratory tract diseases

Enzyme mouth spray could shorten cold duration

ColdZyme, an oral spray containing a proteolytic enzyme, had significant effects on symptoms of sore throat, nose congestion and headache, study finds.

Rhinovirus

Source: Shutterstock.com

ColdZyme, an oral spray barrier solution containing glycerol and the enzyme trypsin had significant effects on symptoms of sore throat, nose congestion and headache, researchers have found

An oral spray containing a proteolytic enzyme reduced the severity and duration of the common cold, a randomised study has found[1].

The trial involved 267 participants with a naturally occurring common cold, who were randomly assigned to use the spray, marketed as ColdZyme by Swedish life science company Enzymatica, six times daily within the first day of symptoms, or receive no treatment.

The researchers found that overall symptom scores on the Jackson cold scale within the first seven days were lower in the ColdZyme-treated group (area under the curve: 39.6 vs. 46.2). There were significant effects on the individual symptoms of sore throat, nose congestion and headache. Quality-of-life scores for all domains were improved and disease duration was shorter in the ColdZyme group.

The ColdZyme spray is a barrier solution containing glycerol and the enzyme trypsin, obtained from the Atlantic cod. Previous in vitro research showed that it can inactivate 99% of viruses that cause the common cold, including influenza and rhinovirus.

“The extremely convincing study results enable us to show the specific clinical benefit of using ColdZyme,” said Fredrik Lindberg, chief medical officer of Enzymatica, who presented the findings at the Icelandic Medical Association conference on 24 January 2019.

ColdZyme is licensed for use in the UK.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2019.20206215

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.