Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Cardiovascular agents

Failure to restart ARB therapy after surgery linked to higher mortality

In a multivariate analysis, 30-day mortality was significantly higher in patients who had not restarted Angiotensin receptor blockers (ARBs) by day 2 after an operation compared with those who had. The risk was even higher in patients under 60 years


Researchers have identified a link between higher mortality and a failure to restart angiotensin receptor blocker therapy after non-cardiac surgery

Angiotensin receptor blockers (ARBs) are widely used by patients with heart disease or hypertension but little is known about how to manage these drugs perioperatively. To investigate this, US researchers performed a retrospective study of 30,173 patients in the Veterans Affairs Healthcare system admitted for noncardiac surgery between 1999 and 2011, published in Anesthesiology[1] on 30 May 2015.

Although all patients were taking ARBs before surgery, there was variation in when the drugs were resumed postoperatively, from the day of surgery to never. Two-thirds of patients had restarted ARBs by day 2 and 80% by day 30. In a multivariate analysis, 30-day mortality was significantly higher in patients who had not restarted ARBs by day 2 compared with those who had (adjusted hazard ratio 1.74); the risk was even higher in younger patients (<60 years). 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068764

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Basic Pharmacokinetics

    Basic Pharmacokinetics

    A clear and concise basic pharmacokinetics textbook. Shows how to apply the principles to achieve successful drug therapy.

    £54.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £43.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.