Drug development
First-in-class drug for sepsis and acute respiratory distress syndrome on the horizon
Researchers at Queen’s University in Belfast are developing a new anti-inflammatory drug that could help treat sepsis and acute respiratory syndrome
Source: Courtesy of Queen’s university, Belfast
Chris Scott from Queen’s University, Belfast, School of Pharmacy
Sepsis is a leading cause of death in hospitalised patients, yet there is no effective treatment. Around 25% of patients with severe sepsis develop acute respiratory distress syndrome (ARDS), driven by an excessive immune response, and up to 30% of these patients will die.
However, a promising new anti-inflammatory drug, SAN101, is described in Science Translational Medicine (online, 2 September 2015)[1]. It is a nanoparticle that targets sialic acid-binding immunoglobulin-like lectins (siglecs) – important negative regulators of acute inflammatory responses.
SAN101 was “therapeutically beneficial” in a mouse model of sepsis and ARDS. Furthermore, it had an anti-inflammatory effect on human macrophages and relieved symptoms of acute lung injury in an ex vivo lung perfusion model. “We are well on the road to developing a new first-in-class treatment,” says Chris Scott, senior author, from Queen’s University Belfast.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20069327
Recommended from Pharmaceutical Press
- Previous
- Next
Drugs of Abuse
A concise, easy-to-read guide for healthcare professionals who encounter drug abuse.
£38.00Buy now
Pharmaceutical Toxicology
Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.
£40.00Buy now.jpg)
Adverse Drug Reactions
A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.
£38.00Buy now
English Delftware Drug Jars
This beautiful book illustrates the art and history of the collection of English delftware drug jars in the Museum of the Royal Pharmaceutical Society of Great Britain.
£54.00Buy now
Paediatric Drug Handling
Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.
£33.00Buy now
Print 
PDF
Have your say
For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.