Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Cardiovascular diseases

Gaps between clinical guidelines and practice for lipid management in Europe, researchers find

A study has found that less than 60% of patients receiving lipid-lowering therapy achieve the low-density lipoprotein cholesterol levels set out in European guidelines.



Researchers said the findings of the study highlighted a gap between treatment guidelines and clinical practice

Less than 60% of patients receiving lipid-lowering therapy achieve the low-density lipoprotein cholesterol (LDL-C) levels set out in European guidelines, a cross-sectional study in the European Journal of Preventive Cardiology has revealed (28 August 2020)[1].

The research included 5,888 patients from 18 European countries, including 3,000 patients treated for primary prevention and 2,888 patients treated for secondary prevention. The team assessed LDL-C levels against the 2016 European Society of Cardiology/European Atherosclerosis Society guidelines, which prescribed targets according to cardiovascular risk level.

Overall, 54% achieved the LDL-C goal for their risk level. Among patients receiving high-intensity statin monotherapy, LDL-C goals were achieved by 22% of very high-risk primary prevention patients and 45% of secondary prevention patients. Moderate-intensity statin monotherapy was the most common regimen and combination regimens with ezetimibe (9%) or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (1%) were rare.

In 2019, the guidelines were updated with even more stringent criteria and, according to these, only 33% met the treatment goal. The researchers said the findings highlighted a “gap” between treatment guidelines and clinical practice.

“Even with optimised statin usage, the prevalent gap between guideline recommended LDL-C goals and their implementation in clinical care will require greater utilisation of non-statin [lipid-lowering therapy] in combination with statins for patients at highest risk,” they concluded.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2020.20208397

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Patient Care in Community Practice

    Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £22.00Buy now
  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00Buy now
  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now
  • Strategic Medicines Management

    Strategic Medicines Management

    A practical guide to influencing the availability of medicines, and policies of their use. Focuses on the strategic elements of medicines management.

    £33.00Buy now
  • Adverse Drug Reactions

    Adverse Drug Reactions

    A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.

    £38.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.