Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Vitamin D

Genetic study finds no evidence vitamin D linked to atopic disease

Findings suggest that association between vitamin D and atopic disease is explained by confounding factors.

Observational studies have suggested that low levels of vitamin D might increase the risk of asthma, atopic dermatitis and raised immunoglobulin E (IgE) levels. However, randomised trials have provided inconclusive results.

In a study in PLoS Medicine[1] (online, 9 May 2017), researchers used a method that minimises the risk of bias owing to confounding and reverse causation, called Mendelian randomisation, to study the effect of four genetic variants associated with vitamin D levels.

The team found there was no significant association between any of the variants and the risk of asthma (n=146,761), childhood-onset asthma (n=15,008), atopic dermatitis (n=40,835) or elevated IgE levels (n=12,853).

They say the results indicate that the previously reported associations between vitamin D and atopic disease were most likely to be due to confounding and that vitamin D supplementation is therefore unlikely to decrease rates of these conditions.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202838

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Close up of skin with atopic dermatitis

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.