Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Goserelin protects against ovarian failure in women treated for breast cancer

Gonadotropin-releasing hormone agonist goserelin can help protect against ovarian failure in women treated for breast cancer., study finds


Ovarian failure is a common and distressing side effect of chemotherapy. The results of a major international trial, published in The New England Journal of Medicine[1] (online, 5 March 2015), suggest that the gonadotropin-releasing hormone agonist goserelin (Zoladex) can help protect against this side effect and improve prospects for fertility.

The prevention of early menopause study S0230 trial included 257 premenopausal women with operable hormone-receptor-negative breast cancer receiving standard chemotherapy, 135 of whom were included in the final analysis. The ovarian failure rate was 8% among women who took goserelin versus 22% among those who did not, giving an odds ratio of 0.30 (95% confidence interval 0.09-0.97).

Women who received goserelin were also significantly more likely to become pregnant and had better disease-free and overall survival than women who did not take the drug.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068093

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.