Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

sections

Nervous system diseases

Gut microbiome altered in Parkinson’s disease

constipation 14

Source: PHOTOTAKE Inc. / Alamy

Constipation (shown in the X-ray image) may precede the onset of motor symptoms in Parkinson’s disease by many years

Gastrointestinal dysfunction, in particular constipation, affects up to 80% of Parkinson’s disease (PD) patients and may precede the onset of motor symptoms by many years. Now, researchers have found that the gut microbiome in PD patients differs from that in healthy individuals.

By analysing stool samples, Filip Scheperjans, from the University of Helsinki, and colleagues found that the quantity of bacteria from the Prevotellaceae family was 77.6% lower in PD patients compared with controls. Meanwhile, the amount of Enterobacteriaceae was positively correlated with the severity of postural instability and gait difficulty in PD patients.

“These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype,” write the authors in Movement Disorders[1] (online, 5 December 2014).

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067471

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Pathology and Therapeutics for Pharmacists

    Pathology and Therapeutics for Pharmacists

    An practical, integrated approach to the pathophysiological and pharmacotherapeutic principles underlying the treatment of disease.

    £54.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • Biological Therapeutics

    Biological Therapeutics

    An introduction to the treatment of disease using biological medicines derived from living plant and animal tissues.

    £33.00Buy now
  • Disease Management

    Disease Management

    Disease Management covers the diseases commonly encountered in primary care by system, with common therapeutic issues. Includes case studies and self-assessment sections.

    £54.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.