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Drug resistance

HIV resistance to tenofovir surprisingly common

International study finds high proportion of HIV patients were resistant to cART drug tenofovir.

International study finds high proportion of HIV patients were resistant to cART drug tenofovir. In the image, micrograph of HIV budding from a lymphocyte

Source: C Goldsmith / CDC

HIV (pictured in green budding from lymphocyte) was resistant to tenofovir in 57% of patients in sub-Saharan Africa who failed first-line treatment 

Treatment and prevention of HIV is reliant upon combination antiretroviral therapy (cART). Tenofovir is an essential component of first-line cART and also prophylaxis. But few data exist on the frequency of drug resistance in low and middle income countries. 

To address this, an international study analysed data from 1,926 people across 36 countries. A high proportion of HIV-infected patients who fail to respond to first-line treatment were resistant to tenofovir. The highest rate was in sub-Saharan Africa at 57%; in Western Europe, the rate was 20%. Patients with tenofovir resistance also frequently developed resistance to other drugs in their regimen. 

Reporting in The Lancet Infectious Diseases (online, 28 January 2016)[1], the team say that better HIV care and surveillance for tenofovir resistance are needed to help prolong the lifetime of tenofovir-containing cART and prophylactic regimens.

 

Citation: Clinical Pharmacist DOI: 10.1211/CP.2016.20200672

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  • International study finds high proportion of HIV patients were resistant to cART drug tenofovir. In the image, micrograph of HIV budding from a lymphocyte

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