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Cancer care

Hormone suppression therapy may harm survival for African-American prostate cancer patients

Androgen-deprivation therapy may shorten survival in African-American men with favourable-risk prostate cancer, researchers say.

X-ray of prostate cancer radiotherapy, or brachytherapy

Source: Dr P Marazzi / Science Photo Library

Hormone therapy is used to shrink prostate cancer tumours prior to radiation therapy (pictured)

It is unclear whether androgen-deprivation therapy (ADT) to reduce prostate size prior to radiation therapy (brachytherapy) is beneficial in African-American men with prostate cancer (PCa). 

To explore, researchers carried out a retrospective study looking at 7,252 men with low-risk or favourable intermediate-risk PCa who underwent brachytherapy with (n=1,501) or without neoadjuvant ADT. 

Over a median follow-up of eight years, the risk of all-cause (hazard rati0 [HR]: 1.77) or other-cause mortality (HR: 1.86) was significantly higher among African-American men compared with non-African American men who received ADT. But among men not receiving ADT, mortality risks were comparable between African Americans and non-African Americans. 

Writing in Cancer (online, 4 August 2016)[1], the researchers say that ADT may shorten survival in African-American men with favourable-risk PCa, and the treatment should therefore be reserved for African-American men with higher risk disease.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2016.20201574

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Supplementary images

  • X-ray of prostate cancer radiotherapy, or brachytherapy

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