Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Insulin degludec significantly improves blood sugar control compared with insulin glargine, data show

Using electronic health record data, researchers found that HbA1c levels declined by 1.5% among insulin degludec-treated patients compared with 1.2% in those treated with insulin glargine U300 over six months.

Degludec insulin molecule

Source: Science Photo Library

In a large study using real-world data, researchers found that insulin degludec (pictured) reduces the rate of hypoglycaemia compared with insulin glargine

Treatment with insulin degludec (Tresiba; Novo Nordisk) in type 2 diabetes mellitus (T2DM) improves glycaemic control and leads to fewer hypoglycaemic episodes compared with insulin glargine, according to results from a study of real-world data, presented at the American Diabetes Association Scientific Sessions in Orlando, Florida, on 25 June 2018[1].

Using electronic health records, researchers used data from 2,028 patients with T2DM who had their treatment intensified with insulin degludec injection and compared them with an equal number of patients whose treatment was intensified with insulin glargine U300 (Toujeo; Sanofi), a basal insulin approved by the European Commission in January 2013.

Between baseline and six months, HbA1c levels declined by an average of 1.5% in the degludec group, compared with 1.2% in the glargine group — a significant difference.

Additionally, the rate of reported hypoglycaemic episodes was 30% lower in the degludec-treated patients compared with glargine-treated patients. Glargine-treated patients were also 37% more likely to discontinue their therapy than degludec-treated patients, the researchers found.

Data from clinical trials indicate that insulin degludec reduces the rate of hypoglycaemia compared with insulin glargine, but the researchers said this is the largest study using real-world data to demonstrate this.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20205369

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines.

    £33.00Buy now
  • Handbook of Drug Administration via Enteral Feeding Tubes

    Handbook of Drug Administration via Enteral Feeding Tubes

    All you need to know about prescribing or administering drugs via enteral feeding tubes. Over 400 drug monographs as well as facts to inform clinical decision making.

    £54.00Buy now
  • Integrated Pharmacy Case Studies

    Integrated Pharmacy Case Studies

    Over 90 case studies based on real life patient-care scenarios. Each case includes learning outcomes and references.

    £47.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £43.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Degludec insulin molecule

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.