Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Parasitic diseases

Large malaria genome study highlights surprising number of potential drug targets

A large-scale study of Plasmodium berghei gene function reveals an abundance of essential parasite genes that could be targets for new antimalarial drugs.

Micrograph of Plasmodium berghei

Source: Sinclair Stammers / Science Photo Library

In the first large-scale study of malaria gene function, researchers at the Wellcome Trust Sanger Institute analysed more than half of the genes in the genome of one species of malaria parasite, Plasmodium berghei

The genomes of malaria parasites contain many genes of unknown function. However, knowing the genes and pathways that contribute to parasite growth is critical to guiding the discovery of new drug targets.

In the first large-scale study of malaria gene function, researchers at the Wellcome Trust Sanger Institute analysed more than half of the genes in the genome of one species of malaria parasite, Plasmodium berghei. To do this, they measured the growth rates in mice of 2,578 P. berghei knockout mutants, each of which were tagged with a unique barcode.

It was found that during a single blood stage of its life cycle, the P. berghei parasite requires around two-thirds of the genes looked at to develop normally.

Publishing their results in Cell[1] (13 July), the researchers say that this shows there are many more potential targets for new antimalarial drug development than previously thought.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203236

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Drugs of Abuse

    Drugs of Abuse

    A concise, easy-to-read guide for healthcare professionals who encounter drug abuse.

    £38.00Buy now
  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now
  • Adverse Drug Reactions

    Adverse Drug Reactions

    A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.

    £38.00Buy now
  • English Delftware Drug Jars

    English Delftware Drug Jars

    This beautiful book illustrates the art and history of the collection of English delftware drug jars in the Museum of the Royal Pharmaceutical Society of Great Britain.

    £54.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Micrograph of Plasmodium berghei

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.