Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Antibiotics

New antibiotic effective against multi-drug resistant Gram-negative UTI

Researchers conclude that cefiderocol, which is also being trialled in lung and blood infections, could be used to overcome Gram-negative resistance.

Urine dipstick test

Source: Shutterstock.com

Among those who tested positive for a Gram-negative uropathogen, 73% in the cefiderocol group and 55% in the imipenem-cilastatin group were considered cured after treatment, indicating that cefiderocol is at least as effective as imipenem-cilastatin

A new antibiotic designed to overcome multi-drug resistance is at least as effective as the current standard of care in complicated urinary tract infection (UTI), according to trial results published in The Lancet Infectious Diseases (25 October 2018)[1].

The trial randomly assigned 303 people to an intravenous infusion of new antibiotic cefiderocol and 149 to the standard of care imipenem-cilastatin, three times daily for 7–14 days.

Among those who tested positive for a Gram-negative uropathogen at baseline, 73% in the cefiderocol group and 55% in the imipenem-cilastatin group were considered cured after treatment, indicating non-inferiority of cefiderocol. There were also fewer adverse events in the cefiderocol group compared with standard care.

Cefiderocol is a cephalosporin antibiotic that contains a siderophore side chain. This component helps the antibiotic overcome the resistance mechanisms evolved by Gram-negative bacteria to existing antibiotics by hijacking the bacteria’s iron transport mechanism to gain entry to the cell.

The researchers said the findings indicate the promise of the drug, which is also being trialled in lung and blood infections, including in carbapenem-resistant infections.

“As a siderophore antibiotic, cefiderocol is a novel approach that might be used to overcome Gram-negative resistance,” the authors concluded.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20205740

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Dale and Appelbe's Pharmacy and Medicines Law

    Dale and Appelbe's Pharmacy and Medicines Law

    This new edition of Dale and Appelbe's Pharmacy and Medicines Law is the definitive guide to law and ethics for pharmacy practice in the UK. It covers law and professional regulation and is firmly established as the definitive student textbook and reference work on this subject in the UK. Fully updated to include changes to pharmacy laws and regulation.

    £57.00Buy now
  • Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines.

    £33.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now
  • Foundation in Pharmacy Practice

    Foundation in Pharmacy Practice

    A practical and succinct overview of the principal pharmacy practice topics, for new pharmacy students.

    £33.00Buy now
  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.