Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Drug discovery

New technique produces chirally pure molecules


Source: Razvan Ionut Dragomirescu/Dreamstime

US scientists develop new technique for creating molecules that could aid drug discovery

Activation reactions – in which carbon–hydrogen (C–H) bonds are broken to create new molecules – is a promising area of drug development. US researchers have made a breakthrough by developing a new technique to create chiral (“one-handed”) molecules.

In research published in Science (online, 24 October 2014[1]), Jin-Quan Yu from The Scripps Research Institute in La Jolla, California, and colleagues used the metal palladium plus an amino acid to act as a catalyst to break C–H bonds, followed by iodination. The amino acid ligand is able to select which enantiomer of the starting material to react with. Once the palladium breaks the C-H bonds of the desired chiral molecules, iodine replaces the removed hydrogen.

“That iodine is the magic, it can be replaced with anything as medicinal chemists wish,” says Yu. “This opens a new avenue to create chirally pure molecules for drug discovery.”

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066945

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now
  • Foundation in Pharmacy Practice

    Foundation in Pharmacy Practice

    A practical and succinct overview of the principal pharmacy practice topics, for new pharmacy students.

    £33.00Buy now
  • Non-medical Prescribing

    Non-medical Prescribing

    An essential new guide designed to ensure confident prescribing in specialist areas.

    £27.00Buy now
  • Dale and Appelbe's Pharmacy and Medicines Law

    Dale and Appelbe's Pharmacy and Medicines Law

    This new edition of Dale and Appelbe's Pharmacy and Medicines Law is the definitive guide to law and ethics for pharmacy practice in the UK. It covers law and professional regulation and is firmly established as the definitive student textbook and reference work on this subject in the UK. Fully updated to include changes to pharmacy laws and regulation.

    £57.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.