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Novel menopause treatment rapidly reduces hot flashes

Research has shown that neurokinin 3 receptor antagonism has a rapid effect on vasomotor symptoms of menopause 

Vasomotor symptoms affect 70% of postmenopausal women and, along with sleep disturbance, are among the most bothersome reported symptoms.

In a placebo-controlled trial reported in Menopause (online, 12 March 2018), researchers explored the efficacy of a neurokinin 3 receptor antagonist known as MLE4901 on hot flashes in 37 women aged 40–62 years with vasomotor symptoms[1].

The team found that by day 3 of treatment, hot flash frequency had reduced in the active treatment group by 51 percentage points compared with placebo. Women who received MLE4901 also reported significant reductions in hot flash severity, interference with daily life, and improvements in sleep and concentration by day 3. These effects were sustained throughout the four-week study period.

The researchers concluded that the results indicate neurokinin 3 receptor antagonism has a rapid effect on vasomotor symptoms of menopause and could provide an effective alternative to oestrogen therapy.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20204615

Readers' comments (1)

  • I had all wikipedia effects of neurokinin, during my menopause experience. Muscle spasms and twitching, gripes, uterine cramps, repeated transient B.P. elevations, acute post -flash diuresis, neurogenic bladder-like symptoms, memory issues, extremely lowered pain threshold-to the point that the touch of water turned unbearable, and much more. I would have been an ideal candidate for use of this Neurokinin antagonist. Neurokinin, however, has a critical role in the nervous, pulmonary, and cardiovascular systems, and also in inflammation and tissue repair, elimination of which could be possibly harmful. Admittedly thus, i could be hesitant to use it, particularly my being a physician!
    Maria Jasmine Freeman

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