Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Drug safety

NSAID users see an increased risk of venous thrombosis, study shows

Some non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of venous thrombosis, study finds

Source: Dr Gladden Willis / Visuals Unlimited, Inc / Science Photo Library

Risk of venous thrombosis was increased for users of non-steroidal anti-inflammatory drugs

Some non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of arterial thrombosis. New findings from a systematic review and meta-analysis suggest that NSAIDs also increase the risk of venous thrombosis.

The study, published in Rheumatology (online, 24 September 2014), included five case–control studies and one cohort study with a total of 21,401 venous thromboembolic events (VTEs). The pooled risk ratio of VTE was 1.8 (95% confidence interval 1.28-2.52) for users of any NSAID and 1.99 (95% CI 1.44-2.75) among users of selective COX-2 inhibitors, versus non-users[1].

The study authors, led by Patompong Ungprasert from Columbia University, New York, note that this is the first meta-analysis to investigate the association between NSAIDs and VTE. “NSAIDs should be prescribed with caution, especially in patients at high baseline risk of VTE,” they warn.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066662

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.