Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Opioid analgesics

Oxycodone may be riskier than other addictive opioids, research suggests

Oxycodone (light micrograph of oxycodone crystals pictured) may be riskier than other opioids, study finds

Source: J. L. Carson, Custom Medical Stock Photo / Science Photo Library

Oxycodone (pictured as crystals) led to a stable rise in dopamine levels, research has found

Although all prescription opioids can be abused, oxycodone may be more potent in its ability to promote changes in the brain relevant to addiction.

Opioids such as morphine and oxycodone are prescribed for pain management but are also drugs of abuse. While the mechanisms underlying drug addiction are not fully understood, research published in the European Journal of Neuroscience[1] (online, 11 September 2014) reveals “dramatic differences” between oxycodone and morphine in their impact on dopamine transmission in the brain.

Rats given morphine showed a brief, transient increase in dopamine and GABA levels, which rapidly returned to baseline. By contrast, oxycodone led to a “robust and stable” rise in dopamine and markedly increased dopamine release events.

“Investigating these differences may be essential for understanding how these two drugs of abuse could differentially usurp motivational circuitry and powerfully influence behaviour,” say Brandon Aragona, from the University of Michigan, and co-authors.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066766

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.