Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Paediatrics

Paediatric epilepsy drug response linked to common genetic variants

Identification of genetic variants predicting seizure status in children could lead to precision medicine approaches for epilepsy.

Child with epilepsy undergoing EEG brain scan

Source: BSIP SA / Alamy Stock Photo

Study suggests that identifying relevant biomarkers for childhood absence epilsepy drug response could lead to precision medicine approaches for the condition

Recent research has shown that patients with childhood absence epilepsy (CAE), the most common form of paediatric epilepsy, have highly variable responses to antiepileptic medications.

To explore why this is the case, researchers studied variations in four genes encoding targets of the drugs in 357 children with CAE randomly assigned to ethosuximide, lamotrigine or valproate.

Between weeks 16 and 20 of the study, 115 (32.2%) patients had experienced a seizure. The researchers identified two genetic variants that appeared most commonly in those who experienced a seizure while taking ethosuximide (P=0.011, odds ratio [OR]=2.63, 95% confidence limits [CL]: 1.25–5.56; P=0.026, OR: 2.38, 95% CL: 1.11–5.00) and three that predicted seizure status in lamotrigine-treated patients. No common variants were found to be associated with valproate.

Reporting in the Annals of Neurology[1] (25 May 2017), the team suggests that identification of relevant biomarkers for CAE drug response could therefore lead to precision medicine approaches for the condition.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202934

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Child with epilepsy undergoing EEG brain scan

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.