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Immunotherapy

Patient’s own glioblastoma cells used to treat tumour

The glioblastoma cells of a patient are used to treat tumour. In picture, MRI scan of a glioblastoma of a brain tumour

Source: Sherbrooke Connectivity Imaging Lab / Science Photo Library

Glioblastoma cells were extracted during brain surgery and used to treat the patient’s tumour

Glioblastoma is an aggressive form of brain tumour with a poor prognosis. Hopes for a vaccine to tackle the disease are bolstered by positive results from a phase I trial reported in Cancer Immunology and Immunotherapy (online, 14 November 2014)[1].

The vaccine, developed by Larry Harshyne and team at Thomas Jefferson University, Philadelphia, Pennsylvania, consists of the patient’s own glioblastoma cells extracted during brain surgery to remove the tumour. The tumour cells are incubated with an antisense oligodeoxynucleotide directed against the insulin-like growth factor type 1 receptor and then packaged inside a diffusion chamber that is inserted into the patient’s abdomen.

Out of 12 patients, the vaccine elicited a positive clinical response in eight patients and an immune response in six patients. Further clinical trials are planned for January 2015. 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067192

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