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Viral infections

Phase I trial of GlaxoSmithKline’s Ebola vaccine shows it is well tolerated

Phase 1 of the clinical trials of the chimpanzee adenovirus type 3–vectored ebola virus vaccine (cAd3-EBO), developed by GlaxoSmithKline (GSK) shows promising results

Source: Paul Doyle / Alamy

In a phase 1 clinical trial of the chimpanzee adenovirus type 3–vectored ebola virus vaccine, developed by GlaxoSmithKline, no major adverse events were reported

The 2014 outbreak of Ebola virus disease has sparked international efforts to develop a vaccine. One candidate being developed by GlaxoSmithKline (GSK) is a replication-defective recombinant chimpanzee adenovirus type 3–vectored ebolavirus vaccine (cAd3-EBO). It is bivalent, offering protection against the Zaire and Sudan strains, and has already demonstrated activity in a nonhuman primate model.

Now, preliminary results from a Phase I study published in The New England Journal of Medicine (online, 26 November 2014)[1] involving 20 healthy adults indicate that the vaccine is both immunogenic and safe. Immune responses to a single dose of vaccine were dose-dependent and there were no major adverse events, although two participants given the higher dose developed transient fever.

Clinical trials of cAd3-EBO are ongoing. GSK says it could produce one million doses a month by the end of 2015. 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067285

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