Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Antimicrobial resistance

Pinpointing a weakness in bacteria’s protective barrier

Source: Diamond’s microfocus MX beamline I24

The structure of the bacteria’s protective barrer was determined using this beamline

An international team of scientists have identified how gram-negative bacteria build a protective barrier against antibiotics[1].

Their paper, published in Nature reports the first crystal structure of a unique integral membrane lipopolysaccharide translocator. “We have identified the path and gate used by the bacteria to transport the barrier building blocks to the outer surface. Importantly, we have identified that the bacteria would die if the gate is locked,” says lead researcher Changjiang Dong of the University of East Anglia.

Dong adds that his group is developing drug candidates based on the findings and hopes a new therapy can be brought to market in the next couple of years.


Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20065628

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

RPS publications

Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.