Progesterone accelerates recovery from flu virus
Progesterone was found to enhance recovery from influenza in mice and so could also have benefits for humans during disease outbreaks, say researchers
The effect of progesterone-based contraceptives on the immune system has been studied in the context of sexually transmitted infections but not on viral diseases outside the reproductive tract.
Researchers from Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland, administered either progesterone or placebo to progesterone-depleted female mice. The mice were then subjected to an influenza A viral challenge.
The team found that, although progesterone treatment did not confer resistance to influenza infection, it promoted faster recovery by altering inflammation and improving pulmonary repair and function. These effects were mediated by the upregulation of the epidermal growth factor amphiregulin in the lungs, the researchers showed.
Reporting in PLoS Pathogens (online, 15 September 2016), the team concludes that the World Health Organization’s recommendation to increase hormonal contraceptive use during disease outbreaks could have additional benefits on the outcome of infectious diseases.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2016.20201714
Recommended from Pharmaceutical Press
An innovative book which presents statistics in the context of clinical trials conducted during pharmaceutical drug development.