Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Adverse drug effects

Proton pump inhibitors linked with chronic kidney disease

A growing body of evidence has linked proton pump inhibitors with acute kidney injury and now new research has also found links with chronic kidney disease.

Increasing evidence has linked proton pump inhibitors (PPIs) with acute kidney injury and nephritis. In the image, light micrograph of a section of a kidney with kidney disease

Source: Steve Gschmeissner / Science Photo Library

Kidney disease (pictured) is being increasingly linked with the use of proton pump inhibitors, which treat acid reflux

Proton pump inhibitors (PPIs), which treat acid reflux and indigestion, are one of the most commonly prescribed classes of drugs. However, increasing evidence has linked PPIs with acute kidney injury and nephritis. 

Now two studies presented at ASN Kidney Week in San Diego, California, suggest PPIs could be contributing to the growing prevalence of chronic kidney disease (CKD). 

One study followed 10,482 people for 12–15 years and found those taking PPIs at baseline were 50% more likely to develop CKD than non-PPI users[1]. Meanwhile, a second study found that among 71,516 people, those who had ever taken PPIs were 10% more likely to develop CKD over a seven-year follow-up period than those who had never taken them[2]

The researchers say that PPIs, which are frequently prescribed off-label, should therefore only be used when necessary.

Citation: Clinical Pharmacist DOI: 10.1211/PJ.2015.20069640

Readers' comments (2)

  • One of the challenges is how to get patients off PPIs. The number of times we see patients taken off a PPI , only to end up with recurrence of original symptoms, and therefore needing to go back on a PPI.
    Perhaps better guidance on reducing doses over a longer period of time are needed

    Unsuitable or offensive? Report this comment

  • And the routine prescribing of PPIs to protect patients from the side effects of NSAIDs prescribed for chronic pain.

    Unsuitable or offensive? Report this comment

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 1 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £138.50Buy now
  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 2 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £262.50Buy now
  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now
  • Sport and Exercise Medicine for Pharmacists

    Sport and Exercise Medicine for Pharmacists

    All the information you need to provide patients with evidence-based advice on sports and exercise related health matters.

    £27.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Increasing evidence has linked proton pump inhibitors (PPIs) with acute kidney injury and nephritis. In the image, light micrograph of a section of a kidney with kidney disease

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.