Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Pre-clinical research

Research challenges ‘cytokine storm’ hypothesis of Alzheimer’s disease

Recent research shows that interleukin-10 (pictured), an anti-inflammatory cytokine, actually increased the deposition of apolipoprotein E protein in a mouse model of Alzheimer's disease

Source: Ramin Herati / Wikimedia Commons

The inflammation triggered by the innate immune system is thought to promote the progression of Alzheimer’s disease (AD). Various anti-inflammatory strategies have been proposed to tackle this problem, but with little success.

The complexity of the relationship between inflammation and AD pathology is highlighted in research published in Neuron[1], which found that interleukin-10 — an anti-inflammatory cytokine — actually had detrimental effects in a mouse model of AD. It increased the accumulation of amyloid plaques and the deposition of apolipoprotein E protein, which was sequestered in plaques, and exacerbated cognitive impairment.

The researchers say that their unexpected finding counters the prevailing ‘cytokine storm’ hypothesis of AD progression, and demonstrates the complex interplay between innate immunity and proteostasis in neurodegenerative diseases — a process that they term ‘immunoproteostasis’.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20067754

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Pathology and Therapeutics for Pharmacists

    Pathology and Therapeutics for Pharmacists

    An practical, integrated approach to the pathophysiological and pharmacotherapeutic principles underlying the treatment of disease.

    £54.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • International Research in Healthcare

    International Research in Healthcare

    Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.

    £38.00Buy now
  • Biological Therapeutics

    Biological Therapeutics

    An introduction to the treatment of disease using biological medicines derived from living plant and animal tissues.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.