Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Pre-clinical research

Role for memantine in treating binge-eating disorder

Memantine (molecular structure pictured) could be used as a pharmacological treatment for binge-eating disorder, recent study finds

Source: Laguna Design / Science Photo Library

The N-methyl-D-aspartate (NMDA) receptor antagonist memantine was infused directly into rats’ brains, into the area implicated in addictive behaviour

Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is used to treat Alzheimer’s disease and has also been shown to reduce the reinforcing and rewarding effects of drugs of abuse.

Research published in Neuropsychopharmacology (online, 10 November 2014)[1] reveals that memantine infused directly into the area of brain implicated in addictive behaviour, the nucleus accumbens, blocks food-seeking behaviour and compulsive eating of junk food in a rat model of binge eating. Binge-eating disorder is a recognised condition that is hypothesised to result from neuroadaptive mechanisms in areas of the brain that parallel drug and alcohol addiction.

“These findings substantiate a role of memantine as a potential pharmacological treatment for binge-eating disorder,” conclude Karen Smith, from Boston University, and co-authors.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067197

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Memantine (molecular structure pictured) could be used as a pharmacological treatment for binge-eating disorder, recent study finds

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.