Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Scientists develop gold nanoparticles to deliver cisplatin

Cancer cell with nanoparticles

Source: M. Welland

Once the nanoparticles (shown in green) are taken up by the glioblastoma cells, they enter the nucleus (blue) where cisplatin causes DNA damage and cell death

Glioblastoma, the most common and aggressive form of adult brain cancer, has a high mortality rate. Even when initial treatment proves successful, treatment resistance rapidly develops.

Scientists at the University of Cambridge have developed gold nanoparticles containing cisplatin as part of a twofold attack on the cancer. Once the nanoparticles are taken up by the cells, cisplatin causes DNA damage and cell death. This effect is enhanced with radiotherapy, which stimulates the gold particles to release electrons that cause further damage.

Using multidrug resistant cells taken from gliobastoma patients, the researchers have successfully destroyed the diseased cells without treatment resistance emerging, according to results published in Nanoscale (online, 25 July 2014)[1]. The next stage of the research will look at how to make this approach applicable to patients.  


Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20066247

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.