Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Blood-brain barrier

Scientists develop promising in vitro blood-brain barrier model

Scientists have developed an in vitro blood-brain barrier (BBB) model. In the image, a light micrograph of a blood-brain barrier.

Source: C J Guerin, PhD, MRC Toxicology Unit / Science Photo Library

Scientists have developed an in vitro blood-brain barrier (BBB) model (image shows a light micrograph of a BBB)

An altered blood-brain barrier (BBB) in childhood has been linked to cerebral palsy and to complications from traumatic brain injury. Research into these conditions may be facilitated by the availability of a synthetic paediatric BBB on a chip.

Called the B3C, this physiologically realistic model has two compartments – vascular and tissue. In a proof-of-principle study reported in Nature[1], researchers grew rat brain endothelial cells on one side of the chip and then evaluated the barrier formed by the cells under static and flow conditions.

They found that the barrier developed realistic tight junctions and had different permeability depending on the size of the molecule trying to cross to the tissue side, making it a promising in vitro model of BBB function in health and disease.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067326

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.