Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Statins could be linked to reduced risk of ovarian cancer, researchers find

Research has shown that women who naturally inhibit the 3-hydroxy-3-methylglutaryl co-enzyme A reductase — the target of statins — have a lower risk of ovarian cancer.

statin tablets put of pill box


The researchers said that their findings opened up the possibility of repurposing statins to help prevent ovarian cancer

Women who take statins long-term, including those carrying the BRCA1/2 gene mutation, could be less likely to develop ovarian cancer than those who do not, research published in JAMA (18 February 2020) has suggested[1].

The researchers, funded by Cancer Research UK, looked at genetic data from 63,347 women aged 20–100 years, of whom 22,406 had ovarian cancer. They also looked at 31,448 women carrying the BRCA1/2 mutation, 3,887 of whom had ovarian cancer.

Using large-scale genetic data, the researchers evaluated whether inhibition of 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase — the target of statins — lowered ovarian cancer risk.

They estimated that HMG-CoA reductase inhibition could be associated with a 40% reduction in ovarian cancer risk in the general population (odds ratio 0.60; 95% confidence interval [CI] 0.43–0.83), and a 31% reduced risk in women with the BRCA1/2 mutation (hazard ratio 0.69; 95% CI 0.51–0.93). Although, the exact mechanism was unclear.

“Our findings open up the possibility of repurposing a cheap drug to help prevent ovarian cancer — especially in women who are at a higher risk,” said Richard Martin, professor of clinical epidemiology at the University of Bristol.

“It’s incredibly interesting that women whose bodies naturally inhibit the enzyme targeted by statins have a lower risk of ovarian cancer, but we don’t recommend anyone rushes to take statins specifically to reduce ovarian cancer risk because of this study.”

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2020.20207756

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.