Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

sections

Adverse drug events

Studies linking statins and memory loss may be flawed

Researchers suggest that detection bias may be the reason why statins have been associated with memory impairment. In the image, a blister pack of statins

Source: Shutterstock.com

Patients who use lipid-lowering drugs appear to be more at risk of acute memory loss but researchers suspect the link is down to detection bias

Whether or not statins are associated with acute memory impairment is unclear. There are plausible mechanistic explanations for such an effect, but new research has come to an alternative conclusion: detection bias, rather than a causal association.

Researchers harnessed a UK primary care database to compare 482,543 statin users with 482,543 matched nonusers of any lipid-lowering drugs (LLDs) and 26,484 matched users of nonstatin LLDs. Compared with nonusers of any LLD, both statin and nonstatin LLDs were strongly associated with incident acute memory loss diagnosed within the first 30 days after exposure.

“This finding suggests that either all LLDs cause acute memory loss or, perhaps more likely, that the association is the result of a detection bias,” the authors conclude in JAMA Internal Medicine[1] (online, 8 June 2015).

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068766

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00Buy now
  • Prescribing Adult Intravenous Nutrition

    Prescribing Adult Intravenous Nutrition

    A practical guide to the principles and practice of adult intravenous nutrition. With numerous illustrations and case studies.

    £40.00Buy now
  • Workplace Drug Testing

    Workplace Drug Testing

    Explains drug testing regulatory frameworks and all aspects of drug analysis. Case studies of successful programmes are included.

    £81.00Buy now
  • Community Pharmacy Handbook

    Community Pharmacy Handbook

    Community Pharmacy Handbook is a survival guide for community pharmacists and students, answering your practical questions. Includes case studies.

    £33.00Buy now
  • Pharmacy Case Studies

    Pharmacy Case Studies

    Understand the application of therapeutics in clinical practice with Pharmacy Case Studies. This book helps you to demonstrate the knowledge gained during your studies.

    £33.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Researchers suggest that detection bias may be the reason why statins have been associated with memory impairment. In the image, a blister pack of statins

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.