Animal experimentation
Study into colon cancer highlights usefulness of pig model
The pig model can help in developing preventive strategies against gut bacterial dysbiosis and inflammation-promoted diseases, such as colon cancer, researchers find.
Evidence suggests that a high-calorie diet (HCD) can cause colon cancer and that this could be related to colon stem cell dysregulation.
In Cancer Prevention Research (online, 2 June 2017), researchers studied the colonic stem cells of pigs fed an HCD and those of pigs fed a standard diet over 13 weeks[1].
They found that the HCD resulted in colon stem cell proliferation and expansion — two important early markers of colon cancer. They also discovered that pigs maintain two types of stem cells — ASCL-2 positive and BMI-1 positive — in the colon, similar to the human system.
The researchers say the findings are important given that most cases of colon cancer are thought to be related to diet and lifestyle. They also suggest that the pig model could be more relevant than mouse models for the development of preventive and therapeutic agents/strategies against disease as mice lack colonic BMI-1 stem cells.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203465
Recommended from Pharmaceutical Press
- Previous
- Next
International Research in Healthcare
Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.
£38.00Buy now
Lecture Notes in Pharmacy Practice
A comprehensive study guide which summarises the basic principles in pharmacy practice. Clear, bulleted information for quick reference.
£43.00Buy now
Sampson's Textbook of Radiopharmacy
This well-established textbook provides specialised information on the use of radiopharmaceuticals in the detection and treatment of diseases.
£81.00Buy now
Good Pharmacovigilance Practice Guide
An essential guide on pharmacovigilance of medicinal products for human use. Practical advice for developing effective pharmacovigilance systems.
£38.00Buy now
MCQs in Pharmaceutical Calculations
MCQs in Pharmaceutical Calculations will help you to perform calculations accurately and with confidence.
£24.00Buy now
Print 
PDF
Have your say
For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.