Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Antibiotics

Use of antibiotics in young children may disrupt gut microbiome

New research suggests that exposure to antibiotic drugs in early life may disrupt the gut microbiome, with potentially far-reaching consequences. In the image, SEM of lactobacillus case shirota bacteria found in the gut

Source: Power and Syred / Science Photo Library

Treatment with antibiotics affected weight gain and the composition of the microbiome in the gut of mice 

In humans, the intestinal microbiota aids metabolic and immunological development among other functions. New research suggests that exposure to antibiotic drugs in early life may disrupt the gut microbiome, with potentially far-reaching consequences.

In the study, mice were given amoxicillin (a beta-lactam), tylosin (a macrolide) or alternating courses of the two antibiotics, at doses and frequencies representative of those used in young children. Significantly, antibiotic-treated mice gained more weight and developed larger bones compared with control mice. DNA sequencing revealed that antibiotics disrupted the gut microbiome in terms of composition, diversity and maturation rate; they also altered the relative numbers of microbial genes linked with specific metabolic functions.

“These observations raise the possibility that early-life antibiotic treatment may influence metabolic phenotypes in humans,” say the researchers in Nature Communications (online, 30 June 2015).

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068961

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • BNF for Children (BNFC) 2017-2018

    BNF for Children (BNFC) 2017-2018

    The BNFC contains essential practical information for all healthcare professionals involved in prescribing, dispensing, monitoring and administration of medicines to children.

    £57.50Buy now
  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 2 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £252.00Buy now
  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 1 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £133.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now
  • Nurse Prescribers' Formulary

    Nurse Prescribers' Formulary

    Essential reference for Community Practitioner Nurse Prescribers. Provides an overview of common conditions and details of medicines that may be prescribed.

    £17.99Buy now
  • Medicines Use Reviews

    Medicines Use Reviews

    Conduct successful Medicines Use Reviews (MURs) with this comprehensive book. Contains evidence-based information, tips and guidance.

    £27.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • New research suggests that exposure to antibiotic drugs in early life may disrupt the gut microbiome, with potentially far-reaching consequences. In the image, SEM of lactobacillus case shirota bacteria found in the gut

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.