Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

sections

Adverse drug events

Use of NSAIDs associated with surgery complication

Recent small studies have raised concerns that use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients undergoing surgery may be associated with anastomotic leak at the surgical junction

Source: bibiphoto / Shutterstock.com

Patients undergoing surgery who take non-steroidal anti-inflammatory drugs may be at risk of anastomotic leak at the surgical junction, say researchers

Recent small studies have raised concerns that use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients undergoing surgery may be associated with anastomotic leak at the surgical junction. Now, a retrospective analysis of more than 13,000 patients undergoing bariatric or colorectal surgery has confirmed this link.

The rate of anastomotic leaks at 90 days was significantly higher in patients who took NSAIDs post-operatively than in those who did not, with a multivariate-adjusted odds ratio (OR) of 1.24 (95% confidence interval 1.01–1.56). The risk was greatest in the subset of patients undergoing non-elective colorectal resection, with an OR of 1.70 (95% CI 1.11–2.68).

“These data may be enough for some surgeons to alter practice patterns,” the study authors conclude in JAMA Surgery (online, 21 January 2015)[1].

 

 

 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20067678

Readers' comments (1)

  • Interesting - may need a review of enhanced recovery pathways within surgery in view of findings as NSAIDS recommended to reduced opioid use.

    Unsuitable or offensive? Report this comment

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Patient Care in Community Practice

    Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £22.00Buy now
  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00Buy now
  • Strategic Medicines Management

    Strategic Medicines Management

    A practical guide to influencing the availability of medicines, and policies of their use. Focuses on the strategic elements of medicines management.

    £33.00Buy now
  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £38.00Buy now
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.