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Adverse drug reactions

Valbenazine shows efficacy for tardive dyskinesia in phase III trial

Promising results in the search for a drug to treat this involuntary movement disorder.

Tardive dyskinesia is a term used to describe involuntary movements of the face or body and can be a side effect of chronic exposure to antipsychotics.

In a phase III study, researchers compared the efficacy of a novel treatment for the condition, valbenazine, at two different doses (40 and 80 mg/day), to placebo, in 225 people with moderate or severe tardive dyskinesia.

Molecular structure of valbenazine

Source: Ed / Wikipedia

Researchers have concluded that once-daily valbenazine could be an effective treatment for tardive dyskinesia.

After six weeks, dyskinesia, as measured by the Abnormal Involuntary Movement Scale, was virtually unchanged in the placebo group at a mean of -0.1 units. A significantly greater decrease was observed in the active treatment groups at a mean of -1.9 units in the 40mg/day group and -3.2 units in the 80mg/day group.

Reporting in the American Journal of Psychiatry[1] (online, 21 March 2017), the team says the results indicate once-daily valbenazine could be an effective treatment for tardive dyskinesia. It was approved by the US Food and Drug Administration in April 2017.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202743

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Supplementary images

  • Molecular structure of valbenazine

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