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University of Oxford

ChAdOx1 nCoV-19 vaccine induces immune response and is safe in humans, early trial data suggests

The University of Oxford’s ChAdOx1 nCoV-19 vaccine induces a strong immune response with no serious adverse reactions, preliminary findings of a phase I/II trial published in The Lancet have suggested.

Anticoagulants

Clarithromycin linked to increased haemorrhage risk in patients treated with direct oral anticoagulantsSubscription

Older adults taking direct oral anticoagulants are more likely to be admitted to hospital for haemorrhage after receiving clarithromycin compared with azithromycin, a study published in JAMA Internal Medicine has suggested.

Vitamin D

Vitamin D may protect against colitis adverse events in patients taking immune checkpoint inhibitorsSubscription

People with melanoma who take immune checkpoint inhibitors are less likely to develop colitis if they are taking vitamin D supplements at treatment initiation, a study published in the journal Cancer has suggested

Holding hands with someone in a hospital bed

Anticipatory prescribing practices rapidly changing under COVID-19

The COVID-19 pandemic has led to innovation in anticipatory prescribing practices within community palliative care, the results of a survey in BMJ Supportive & Palliative Care have shown.

statin tablets put of pill box 16

Statins linked to lower risk of death from COVID-19, study suggests

Patients hospitalised with COVID-19 who take statins are less likely to die than those who do not, a retrospective study published in Cell Metabolism suggests.

It should not have taken a pandemic to highlight BAME health inequalities

Disproportionate impact of COVID-19 on BAME populations not explained by cardiometabolic factors, vitamin D or deprivation, researchers findSubscription

Variations in cardiometabolic factors, vitamin D levels and socioeconomic or behavioural factors do not adequately explain why COVID-19 disproportionately affects black, Asian and minority ethnic populations.

Old man with IBD

Inflammatory bowel disease may be linked to increased risk of dementiaSubscription

People with inflammatory bowel disease have a significantly higher risk of developing dementia later in life, a study in Gut has suggested.

Secukinumab and adalimumab comparable for first-line psoriatic arthritis treatment

Secukinumab and adalimumab comparable for first-line psoriatic arthritis treatmentSubscription

Biological therapies secukinumab and adalimumab are similarly effective at improving the musculoskeletal symptoms of psoriatic arthritis, a head-to-head trial suggests.

medication overuse headache

Withdrawal and preventive therapy best management for medication overuse headacheSubscription

Medication overuse headache is best treated with a combination of analgesic withdrawal and pharmaceutical prophylaxis, the authors of a study in JAMA Neurology have said.

Fingerprick test ss20

SGLT2 inhibitors linked to reduced risk of serious renal eventsSubscription

Sodium-glucose co-transporter 2 inhibitors are associated with a lower incidence of serious renal events in people with diabetes, a study in the BMJ has suggested.

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