Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Roflumilast launched as add-on COPD treatment

by News team

Roflumilast, a new medicine for chronic obstructive pulmonary disease, is now available from Merck Sharp & Dohme.

Launched earlier this month under the brand name Daxas, the drug is an add-on to existing bronchodilator treatment and is indicated for maintenance treatment of severe COPD associated with chronic bronchitis in adults with a history of frequent exacerbations.

Patients should check their weight regularly and if an unexplained or clinically concerning weight loss occurs, roflumilast treatment should be stopped. In one-year studies, patients regained body weight by three months after discontinuation, the summary of product characteristics states.

Roflumilast is also associated with an increased risk of psychiatric disorders such as insomnia, anxiety, nervousness and depression.

Adverse effects, including diarrhoea, nausea, abdominal pain and headache, occur mainly in the first few weeks of treatment and most resolve with continued treatment, but in cases of persistent intolerability treatment should be stopped.

The drug may take several weeks to achieve its effects, according to the SPC.

NPC logoOral roflumilast launched as add-on treatment for COPD

Product information

Action Phosphodiesterase type 4 inhibitor

Dose 500µg tablet once daily at the same time every day with or without food

Cost 30 x 500µg tablets, £37.71; 90 x 500µg tablets, £113.14

 

Citation: The Pharmaceutical Journal URI: 11026361

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Daxas pack shot

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.