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SSRIs have more effect on personality than depression, study suggests

Selective serotonin reuptake inhibitors could improve patients’ extraversion and reduce neurotic behaviours independent of their effect on depression, research suggests (Archives of General Psychiatry 2009;66:1322).

In the study of 240 patients with depression, those taking paroxetine experienced greater personality change than placebo-treated ones, even after controlling for improvements in depression (reduced neuroticism, P<0.001; increased extraversion, P=0.002).

The authors suggest the findings “support the notion that SSRIs’ effects on personality go beyond and perhaps contribute to their antidepressant effects”.

Citation: Clinical Pharmacist URI: 10990700

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