Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Systematic errors affect transfer of animal data to clinical trials

False positive and false negative results may be leading to systematic errors in the ways in which data from animal studies are applied to clinical trials, a study suggests.

Ian Roberts, professor of epidemiology at the London School of Hygiene and Tropical Medicine, compared animal and human studies of six different interventions. He acknowledges that his sample size is too small to give estimates of the extent of agreement between the studies but found a lack of communication between those conducting animal experiments and the corresponding clinical trials.

For instance, he found examples of animal studies being conducted alongside clinical trials of the same intervention and animal researchers speculating possible benefits in humans from treatments already shown to cause harm in large-scale clinical trials. He argues that closer collaboration between those involved in animal research and clinical trials is needed.

Professor Roberts’s report is available to download

Last week the Medical Research Council and the Wellcome Trust published a booklet explaining why they believe that the use of primates in medical research continues to be necessary while the British Union for the Abolition of Vivisection called for all experiments on primates to be banned throughout Europe.

The MRC and Wellcome Trust say that the scientific consensus at present is that the use of primates is justified in a small number of specific circumstances. “There is a need to review constantly the ethical and scientific justification for primate use, since both research ethics and science are developing fields,” they add.

Citation: The Pharmaceutical Journal URI: 10022143

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00Buy now
  • Pharmaceutical Toxicology

    Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

    £40.00Buy now
  • Adverse Drug Reactions

    Adverse Drug Reactions

    A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.

    £38.00Buy now
  • MCQs in Clinical Pharmacy

    MCQs in Clinical Pharmacy

    Four practice tests, each with 80 practice-oriented MCQs. Assess your knowledge of clinical issues, evaluative and analytical skills.

    £25.00Buy now
  • Pathology and Therapeutics for Pharmacists

    Pathology and Therapeutics for Pharmacists

    An practical, integrated approach to the pathophysiological and pharmacotherapeutic principles underlying the treatment of disease.

    £54.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.